Your skin — upgraded.
Award-winning injectables, skin, hair loss and anti-wrinkle treatments in Manchester's Northern Quarter. Subtle, natural results — never overdone. Est. 2019 by Doctor Tina Bani .
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Let our doctor-led team design a bespoke plan entirely around you.
"Results that look completely like me — just refreshed."
Sara · Skiin Client
Your skin — upgraded.
Award-winning injectables, skin, hair loss and anti-wrinkle treatments in Manchester's Northern Quarter. Subtle, natural results — never overdone. Est. 2019 by Doctor Tina Bani .
Regenerative Skin Treatment · Manchester
Advanced polynucleotide (PDRN) skin regeneration in Manchester — stimulating genuine tissue repair, collagen production and vascular growth for true cellular renewal. Best known for regenerating the delicate under-eye area and brightening dark circles.
Cellular Regeneration
DNA-level tissue repair
Anti-Inflammatory
Reduces chronic skin inflammation
3-Session Course
Cumulative, lasting improvement
Multiple Areas
Face, under-eye, neck, scalp
Real Results
PDRN regenerates skin quality from within — especially the delicate under-eye area. Drag the slider to compare real Skiin patient results.
The Science
Polynucleotides represent one of the most significant advances in regenerative aesthetics of the past decade. Unlike treatments that work by adding volume or temporarily relaxing muscles, PDRN works by communicating with your cells directly — binding to adenosine receptors that control tissue repair and triggering a genuine regenerative cascade.
The effects are multiple: stimulation of fibroblasts (the cells responsible for collagen production), improvement in local blood supply, reduction of chronic inflammation that accelerates skin ageing, and genuine tissue remodelling over time.
The treatment has decades of use in wound healing medicine and sports injury recovery — its application to aesthetic skin medicine is a natural extension of a well-established science. At Skiin, we use premium pharmaceutical-grade PDRN products, administered by our qualified doctors.
The Result
PDRN repairs skin at a cellular level. The change reads as genuinely healthier skin, not as a treatment.
Under-Eye Focus
Feeling personally victimised by your dark circles? You're not alone — the under-eye area is one of the most common concerns we treat at Skiin. Dark circles have many causes: genetics, ethnicity, sun damage and thinning skin all play their part, which is why no single treatment suits everyone.
Skincare has a genuine supporting role. Eye creams containing vitamin C, kojic acid and retinoids can help brighten pigmentation and strengthen thin skin over time — but for many patients, topical products alone can't reach the root of the problem.
In-clinic, polynucleotides are one of the best options for dark circles due to their intensive antioxidant and brightening effects — regenerating the thin under-eye skin so it looks smoother, firmer and naturally brighter over a course of treatment.
One important distinction your doctor will assess at consultation: if the darkness is actually shadowing, as a result of volume deficiency in the tissue, dermal fillers provide the improvement — and the two treatments are often combined for the most complete result.
Why the Cause Matters
Your doctor diagnoses the cause first, then tailors the treatment — dark circles are never one-size-fits-all.
Treatment Areas
Improving overall skin quality, firmness and luminosity across the whole face. Often combined with Profhilo for maximum bioremodelling effect.
The under-eye area responds exceptionally well to PDRN — improving skin quality, tightening crepey texture and reducing hollowness and dark circles.
Often the first area to show visible ageing. Polynucleotides improve skin quality and tightening in areas where filler is not appropriate.
Used in hair restoration protocols to stimulate follicle activity and improve scalp health. See our dedicated hair restoration page.
The Treatment
Day 0
Session 1
Micro-injections of PDRN across the face, under-eye or neck. A 20–30 minute session with mild, brief redness at injection points.
Week 2–4
Session 2
A second session builds on the first. Initial firmness and glow begin to emerge as cellular regeneration gets underway.
Week 6–8
Session 3
The third session completes the course. Texture refines, under-eyes brighten and skin looks genuinely healthier.
Month 3–6
Full result & maintenance
Cumulative regeneration is visible. Maintain with a single session every 3–6 months to sustain the improvement.
Suitability
Thin, crepey or fragile skin — especially under the eyes and on the neck
Dark circles or hollows that make you look tired no matter how much you sleep
Skin that's slow to heal, bounce back or repair itself
You prefer regeneration from within over adding volume with filler
You're happy to build results across an initial course of 3 sessions
Regenerative Cluster
Polynucleotides combine exceptionally well with Profhilo and RF microneedling for comprehensive skin regeneration. Explore our full skin rejuvenation programme.
FAQs
Polynucleotides (PDRN) are purified DNA fragments derived from salmon sperm DNA that stimulate tissue regeneration, collagen production and vascular growth. They work at a cellular level — activating receptors that trigger repair and regeneration rather than simply adding a substance to the skin.
An initial course of 3 sessions spaced 2–4 weeks apart is recommended, followed by maintenance every 3–6 months. Results are cumulative and build over the course of treatment.
Both improve skin quality, but through different mechanisms. Profhilo is hyaluronic acid that stimulates collagen by spreading through the tissue. Polynucleotides work at DNA receptor level, stimulating genuine tissue regeneration. Many patients benefit from both treatments — they are complementary rather than competing.
Yes. Polynucleotides are particularly effective for the delicate under-eye area — improving skin quality, reducing hollowness, tightening crepey texture and addressing dark circles caused by poor skin quality rather than pigmentation.
Often, yes — when the cause is skin quality. Dark circles can stem from genetics, ethnicity, sun damage or thin under-eye skin. Polynucleotides are one of the best in-clinic options for dark circles thanks to their intensive antioxidant and brightening effects, regenerating the skin so it looks smoother and naturally brighter. Eye creams containing vitamin C, kojic acid and retinoids can help at home alongside treatment. If the darkness is actually shadowing caused by volume deficiency in the tissue, dermal filler provides the improvement — your doctor will diagnose the cause before recommending anything.
Polynucleotide treatment at Skiin is priced per session and discussed during consultation. A full course of 3 is typically £600–£900 depending on areas treated. All pricing is transparent.
Polynucleotides have an excellent safety profile with decades of clinical use. The purification process removes allergenicity from the source material. Side effects are typically limited to mild redness and swelling at injection sites, resolving within 24–48 hours.
Both are regenerative treatments that signal your cells to repair rather than simply adding a substance. Polynucleotides (PDRN) are purified salmon DNA fragments with decades of clinical use in wound healing; exosomes are cell-signalling vesicles — the newest frontier in regenerative aesthetics. They can be complementary: many patients use polynucleotides as the foundation of skin regeneration, with exosome therapy to intensify the result. Exosome treatment is available at Skiin Manchester as part of a doctor-designed programme.
After the initial course of 3 sessions, results typically hold for 6–9 months, with many patients extending to 12. Because polynucleotides regenerate skin rather than simply filling it, improvement builds during the course and then fades gradually — maintenance is a single session every 6–9 months rather than starting again. Under-eye areas, where skin is thinnest, often hold their result longest.